|
KMID : 0363320080290030742
|
|
Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 3 p.742 ~ p.751
|
|
|
Effects of Samjawhadam-jeon on Immune Cells in Ovalbumin-induced Asthmatic Mice
|
|
Lee Joung-Eun
Park Yang-Chun
|
|
|
Abstract
|
|
|
Objective: The purpose of this study was to evaluate the effect of Samjawhadam-jeon (SJHDJ; 三子化痰煎) on immune cells in OVA-induced asthmatic mice.
Material and Methods : C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (four times a week) for asthma induction. Two experimental groups were treated with different concentrations of SJHDJ group (400 mg/kg) extracts and cyclosporin A (10 mg/kg) for the latter 8 weeks. At the end of the experiment, the mouse lung. peripheral lymph node (PLN) and spleen were removed and immune cells were analyzed by flow cytometer.
Results : Lung weight, total cells in lung, PLN, and spleen of the SJHDJ group decreased significantly compared with that of the control group. Number of , cells in lung, PLN and spleen, number of cells in PLN and spleen, number of cells in lung and PLN, and number of cells in PLN of the SJHDJ group decreased compared with that of the control group. Number of cells in PLN and spleen of the SJHDJ group increased compared with that of the control group.
Conclusion : These results demonstrate that SJHDJ will be a desirable alternative therapy for allergic asthma by inhibiting the expression of immune cells.
|
|
|
KEYWORD
|
|
|
Samjawhadam-jeon(三子化痰煎), asthma, immune cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|